Blood+ is an anime series based loosely on Blood:The Last Vampire, which was turned into a feature-length movie of the same name. Phew, figuring out that history was tiring.

In terms of enjoyment: Anime > Movie > Anime Series

The Horrible is based on the anime series, where Saya, the main character (the co-sire of all vampires) is followed around by a coffin-wielding vampire as they fight against Saya's sister (the other sire) and minions. It's as convoluted as it sounds.